Soto Lab

Publications

Boyle BR, Melli SE, Altreche RS, Padron ZM, Yousufzai FAK, Kim S, Vasquez MD, Carone DM, Carone BR, Soto I (2020).  NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C. Development 147 (21): dev189019 DOI: 10.1242/dev.189019

Buchanan RA, Foley KE, Pepper KW, Reagan AM, Keezer KJ, Hewes AA, Diemler CA, Preuss C, Soto I, John SWM, Howell GR (2019). Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma. Invest Ophthalmol Vis Sci. Aug 1;60(10):3283-3296. doi: 10.1167/iovs.18-26126.

Onos KD, Uyar A, Keezer KJ, Jackson HM, Preuss C, Acklin CJ, O'Rourke R, Buchanan R, Cossette TL, Sukoff Rizzo SJ, Soto I, Carter GW, Howell GR (2019). Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation. PLoS Genet. 15(5):e1008155. doi: 10.1371/journal.pgen.1008155.

Harder JM, Williams PA, Soto I, Foxworth NE, Fernandes KA, Freeburg NF, Libby RT, John SWM (2018). Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice. Cell Death Dis. 9(6):705. doi: 10.1038/s41419-018-0705-8.

Soto I, Grabowska WA, Onos KD, Graham LC, Jackson HM, Simeone SN, Howell GR (2016). Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. Neurobiol Aging doi 10.16 (in press). PDF

Graham LC, Harder JM, Soto I, de Vries WN, John SW, Howell GR (2016). Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. Sci Rep. 2016 Feb 18;6:21568. doi: 10.1038/srep21568.

Soto I, Graham LC, Richter HJ, Radell JR, Grabowska W, Howell MC, Howell GR (2015). APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction. PLOS Bio, Oct 29, 13(10):e1002279. PDF

Soto I, Howell GR, John CW, Kief JL, Libby RT and John SW (2014).  DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation. PLOS One Sep 10;9(9):e107291.

Howell GR, Soto I*, Ryan M, Graham LC, Smith RS, John SW (2013).  Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice. J Neuroinflammation 10:76. *Co-first author.
 
Jackson HM, Soto I, Graham LC, Carter GW, Howell GR (2013). Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.  BMC Genomics 14:831

 Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, Macnicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW (2012). Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.  J Clin Invest 122: 1246-61.

Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW (2011). Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 43:579-84.

 Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW (2011). Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest. 121:1429-44.

Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, Yang Z, Davis CH, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ, Vidal-Sanz M, Ellisman MH, Marsh-Armstrong N (2011). Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci U S A. 108:1176-81. 
                                 
Soto I, Pease ME, Son J, Shi X, Quigley HA, and Marsh-Armstrong N (2011). Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model is Sectorial and involves Early Optic Nerve Axon Loss and Astrocyte Reactivity. Invest Ophthalmol Vis Sci 52:434-41.

Son J, Soto I*, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, and Marsh-Armstrong N (2010) Glaucomatous Optic Nerve Injury Involves Early Astrocyte Reactivity and Late Oligodendrocyte Loss.  Glia 58:780-9.    *Co-first author.

Blanco RE, Soto I, Duprey-Díaz M, Blagburn JM (2008).  Up-regulation of brain-derived neurotrophic factor by application of fibroblast growth factor-2 to the cut optic nerve is important for long-term survival of retinal ganglion cells. J Neurosci Res 86:3382.

  Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marsh-Armstrong N, Hubbard WC, Calkins DJ, Horner PJ, Vetter ML (2008).  Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci 49:1437-46

  Soto I, Oglesby E, Buckingham BP, Son JL, Roberson ED, Steele MR, Inman DM, Vetter ML, Horner PJ, Marsh-Armstrong N (2008). Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J Neurosci 28: 548-61 (Cover illustration)

Soto I, Lopez-Roca TH, Blagburn J, Blanco RE (2006). Changes in nNOS and NADPH diaphorase in frog retina and tectum after axotomy and FGF-2 application.  Brain Res 1103 (1): 65-75.

  Soto I, Rosenthal J, Blagburn J, Blanco RE (2006). Fibroblast growth factor 2 applied to the optic nerve after axotomy increases BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways. J Neurochem 96:82-96

  Ríos-Muñoz W, Soto I*, Blagburn J, Blanco RE (2005). Fibroblast growth factor 2 applied to the optic nerve after axotomy increases Bcl-2 and Bcl-x and decreases Bax in ganglion cells by activating the ERK signaling pathway. J Neurochem 93: 1422-33. *Co-first author.

Reviews:

Soto I, Krebs M, Reagan A and Howell GR (2019). Vascular Inflammation Risk Factors in Retinal Disease. Annual Review of Vision Science. 5:99-122. doi:10.1146/annurev-vision-091517-034416.

Soto I and Howell GR (2014). The Complex Role of Neuroinflammation in Glaucoma. Cold Spring Harb Perspect Med. Jul 3; 4(8). (Cover illustration)

Howell GR, Soto I, Libby R, John SW (2012). Intrinsic axonal degeneration pathways are critical for glaucomatous damage. Exp Neurol, 246:54-61.

 Nickells RW, Howell GR, Soto I, and John SWM (2012). Under Pressure: Cellular and Molecular Responses in Glaucoma. Annual Review of Neuroscience, Vol. 35: July 2012.

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