Recent Publications

Impacts of Hydrophobic Mismatch on Antimicrobial Peptide Efficacy and Bilayer Permeabilization.
Meier S, Ridgway ZM, Picciano AL, Caputo GA.
Antibiotics (Basel). 2023 Nov 14;12(11):1624. doi: 10.3390/antibiotics12111624. PMID: 37998826

Development of antibacterial neural stimulation electrodes via hierarchical surface restructuring and atomic layer deposition.
Khosla H, Seche W, Ammerman D, Elyahoodayan S, Caputo GA, Hettinger J, Amini S, Feng G.
Sci Rep. 2023 Nov 13;13(1):19778. doi.org/10.1038/s41598-023-47256-9PMID: 37957282

Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications.
Takahashi H, Sovadinova I, Yasuhara K, Vemparala S, Caputo GA, Kuroda K.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Oct 27:e1866. DOI: 10.1002/wnan.1866. Online ahead of print. PMID: 36300561 Review.

Selective Detection and Characterization of Small Cysteine-Containing Peptides with Cluster-Modified Nanopore Sensing.
Ghimire ML, Cox BD, Winn CA, Rockett TW, Schifano NP, Slagle HM, Gonzalez F, Bertino MF, Caputo GA, Reiner JE.
ACS Nano. 2022 Oct 25;16(10):17229-17241. doi: 10.1021/acsnano.2c07842. Epub 2022 Oct 10. PMID: 36214366

Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids.
Patel R, Clark AK, DeStefano G, DeStefano I, Gogoj H, Gray E, Patel AY, Hauner JT, Caputo GA, Vaden TD.
Biochem Biophys Rep. 2022 Mar 8;30:101242. doi: 10.1016/j.bbrep.2022.101242. eCollection 2022 Jul. PMID: 35280523

Investigation of the Role of Hydrophobic Amino Acids on the Structure-Activity Relationship in the Antimicrobial Venom Peptide Ponericin L1.
Schifano NP, Caputo GA.
J Membr Biol. 2022 Oct;255(4-5):537-551. doi: 10.1007/s00232-021-00204-y. Epub 2021 Nov 18. PMID: 34792624 Review.

Mechanistic Study of Membrane Disruption by Antimicrobial Methacrylate Random Copolymers by the Single Giant Vesicle Method.
Tsukamoto M, Zappala E, Caputo GA, Kikuchi JI, Najarian K, Kuroda K, Yasuhara K.
Langmuir. 2021 Aug 24;37(33):9982-9995. doi: 10.1021/acs.langmuir.1c01047. Epub 2021 Aug 11. PMID: 34378943

Investigation of the structure-activity relationship in ponericin L1 from Neoponera goeldii.
Senetra AS, Necelis MR, Caputo GA.
Pept Sci (Hoboken). 2020 May;112(3):e24162. doi: 10.1002/pep2.24162. Epub 2020 Mar 31. PMID: 33937618

Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B.
D'Souza AR, Necelis MR, Kulesha A, Caputo GA, Makhlynets OV.
Biomolecules. 2021 Mar 12;11(3):421. doi: 10.3390/biom11030421. PMID: 33809374

Thermodynamic destabilization of azurin by four different tetramethylguanidinium amino acid ionic liquids.
DeStefano I, DeStefano G, Paradis NJ, Patel R, Clark AK, Gogoj H, Singh G, Jonnalagadda KS, Patel AY, Wu C, Caputo GA, Vaden TD.
Int J Biol Macromol. 2021 Jun 1;180:355-364. doi: 10.1016/j.ijbiomac.2021.03.090. Epub 2021 Mar 17. PMID: 33744247

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria.
Takahashi H, Caputo GA, Kuroda K.
Biomater Sci. 2021 Apr 21;9(8):2758-2767. doi: 10.1039/d0bm01865a. Epub 2021 Feb 18. PMID: 33599647

Effects of Ionic Liquids on Metalloproteins.
Patel AY, Jonnalagadda KS, Paradis N, Vaden TD, Wu C, Caputo GA.
Molecules. 2021 Jan 19;26(2):514. doi: 10.3390/molecules26020514. PMID: 33478102

Synergistic interactions of ionic liquids and antimicrobials improve drug efficacy.
Yang DD, Paterna NJ, Senetra AS, Casey KR, Trieu PD, Caputo GA, Vaden TD, Carone BR.
iScience. 2020 Nov 23;24(1):101853. doi: 10.1016/j.isci.2020.101853. eCollection 2021 Jan 22. PMID: 33364575

Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G.
Hitchner MA, Necelis MR, Shirley D, Caputo GA.
Probiotics Antimicrob Proteins. 2021 Apr;13(2):527-541. doi: 10.1007/s12602-020-09701-3. PMID: 32889698

Investigation of the Role of Aromatic Residues in the Antimicrobial Peptide BuCATHL4B.
Necelis MR, Santiago-Ortiz LE, Caputo GA.
Protein Pept Lett. 2021;28(4):388-402. doi: 10.2174/0929866527666200813202918. PMID: 32798369

Cationic Molecular Umbrellas as Antibacterial Agents with Remarkable Cell-Type Selectivity.
Chen A, Karanastasis A, Casey KR, Necelis M, Carone BR, Caputo GA, Palermo EF.
ACS Appl Mater Interfaces. 2020 May 13;12(19):21270-21282. doi: 10.1021/acsami.9b19076. Epub 2020 Jan 9. PMID: 31917544

Effects of Ionic Liquid Alkyl Chain Length on Denaturation of Myoglobin by Anionic, Cationic, and Zwitterionic Detergents.
Lee JY, Selfridge KM, Kohn EM, Vaden TD, Caputo GA.
Biomolecules. 2019 Jul 8;9(7). pii: E264. doi: 10.3390/biom9070264.

Correlating Lipid Membrane Permeabilities of Imidazolium Ionic Liquids with their Cytotoxicities on Yeast, Bacterial, and Mammalian Cells.
Cook K, Tarnawsky K, Swinton AJ, Yang DD, Senetra AS, Caputo GA, Carone BR, Vaden TD.
Biomolecules. 2019 Jun 25;9(6). pii: E251. doi: 10.3390/biom9060251.

Analyzing Transmembrane Protein and Hydrophobic Helix Topography by Dual Fluorescence Quenching.
Caputo GA, London E.
Methods Mol Biol. 2019;2003:351-368. doi: 10.1007/978-1-4939-9512-7_15.

Activity and characterization of a pH-sensitive antimicrobial peptide.
Hitchner MA, Santiago-Ortiz LE, Necelis MR, Shirley DJ, Palmer TJ, Tarnawsky KE, Vaden TD, Caputo GA.
Biochim Biophys Acta Biomembr. 2019 May 8. pii: S0005-2736(19)30097-5. doi: 10.1016/j.bbamem.2019.05.006

Characterization and Antimicrobial Activity of Amphiphilic Peptide AP3 and Derivative Sequences.
Chrom CL, Renn LM, Caputo GA.
Antibiotics (Basel). 2019 Mar 6;8(1). pii: E20. doi: 10.3390/antibiotics8010020.

Sequence and Dispersity are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s.
Zhou Z, Ergene C, Lee JY, Shirley DJ, Carone BR, Caputo GA, Palermo EF.
ACS Appl Mater Interfaces. 2018 Dec 21. doi: 10.1021/acsami.8b19098

Heme Dissociation from Myoglobin in the Presence of the Zwitterionic Detergent N,N-Dimethyl-N-Dodecylglycine Betaine: Effects of Ionic Liquids.
Kohn EM, Lee JY, Calabro A, Vaden TD, Caputo GA.
Biomolecules. 2018 Oct 29;8(4). pii: E126. doi: 10.3390/biom8040126.

Antimicrobial activity of a porphyrin binding peptide
Shirley DJ, Chrom CL, Richards EA, Carone BR, Caputo GA
Peptide Science. 2018 110. https://doi.org/10.1002/pep2.24074

A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli.
Lupino KM, Romano KA, Simons MJ, Gregg JT, Panepinto L, Cruz GM, Grajek L, Caputo GA, Hickman MJ, Hecht GB.
BMC Microbiol. 2018 Apr 18;18(1):36. doi: 10.1186/s12866-018-1180-1

Role of Cationic Side Chains in the Antimicrobial Activity of C18G.
Kohn EM, Shirley DJ, Arotsky L, Picciano AM, Ridgway Z, Urban MW, Carone BR, Caputo GA.
Molecules. 2018 Feb 4;23(2). pii: E329. doi: 10.3390/molecules23020329.

Effects of Hydrophobic Amino Acid Substitutions on Antimicrobial Peptide Behavior.
Saint Jean KD, Henderson KD, Chrom CL, Abiuso LE, Renn LM, Caputo GA.
Probiotics Antimicrob Proteins. 2017 Nov 4. doi: 10.1007/s12602-017-9345-z.

Silver Oxide Coatings with High Silver-Ion Elution Rates and Characterization of Bactericidal Activity.
Goderecci SS, Kaiser E, Yanakas M, Norris Z, Scaturro J, Oszust R, Medina CD, Waechter F, Heon M, Krchnavek RR, Yu L, Lofland SE, Demarest RM, Caputo GA, Hettinger JD.
Molecules. 2017 Sep 7;22(9). pii: E1487. doi: 10.3390/molecules22091487.

Synergistic effects of polymyxin and ionic liquids on lipid vesicle membrane stability and aggregation.
Hanna SL, Huang JL, Swinton AJ, Caputo GA, Vaden TD.
Biophys Chem. 2017 Aug;227:1-7. doi: 10.1016/j.bpc.2017.05.002. Epub 2017 May 11.

An Experimental and Molecular Dynamics Study of Red Fluorescent Protein mCherry in Novel Aqueous Amino Acid Ionic Liquids.
Borrell KL, Cancglin C, Stinger BL, DeFrates KG, Caputo GA, Wu C, Vaden TD.
J Phys Chem B. 2017 May 11;121(18):4823-4832. doi: 10.1021/acs.jpcb.7b03582. Epub 2017 Apr 27.
Synthetic Random Copolymers as a Molecular Platform To Mimic Host-Defense Antimicrobial Peptides.
Takahashi H, Caputo GA, Vemparala S, Kuroda K.
Bioconjug Chem. 2017 May 17;28(5):1340-1350. doi: 10.1021/acs.bioconjchem.7b00114.

A Cationic Amphiphilic Random Copolymer with pH-Responsive Activity against Methicillin-Resistant Staphylococcus aureus.
Hong S, Takahashi H, Nadres ET, Mortazavian H, Caputo GA, Younger JG, Kuroda K.
PLoS One. 2017 Jan 6;12(1):e0169262. doi: 10.1371/journal.pone.0169262.

Functional characterization of a melittin analog containing a non-natural tryptophan analog.
Ridgway Z, Picciano AL, Gosavi PM, Moroz YS, Angevine CE, Chavis AE, Reiner JE, Korendovych IV, Caputo GA.
Biopolymers. 2015 Jul;104(4):384-94. doi: 10.1002/bip.22624.

Analyzing the effects of hydrophobic mismatch on transmembrane ?-helices using tryptophan fluorescence spectroscopy.
Caputo GA.
Methods Mol Biol. 2013;1063:95-116. doi: 10.1007/978-1-62703-583-5_5.

Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers.
Takahashi H, Palermo EF, Yasuhara K, Caputo GA, Kuroda K.
Macromol Biosci. 2013 Oct;13(10):1285-99. doi: 10.1002/mabi.201300126.

Conductivity, spectroscopic, and computational investigation of H3O+ solvation in ionic liquid BMIBF4.
Yu L, Clifford J, Pham TT, Almaraz E, Perry F 3rd, Caputo GA, Vaden TD.
J Phys Chem B. 2013 Jun 13;117(23):7057-64. doi: 10.1021/jp402582r.

Analyzing transmembrane protein and hydrophobic helix topography by dual fluorescence quenching.
Caputo GA, London E.
Methods Mol Biol. 2013;974:279-95. doi: 10.1007/978-1-62703-275-9_13.

Painting proteins blue: ?-(1-azulenyl)-L-alanine as a probe for studying protein-protein interactions.
Moroz YS, Binder W, Nygren P, Caputo GA, Korendovych IV.
Chem Commun (Camb). 2013 Jan 18;49(5):490-2. doi: 10.1039/c2cc37550h.

Antimicrobial polymers as synthetic mimics of host-defense peptides.
Kuroda K, Caputo GA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan-Feb;5(1):49-66. doi: 10.1002/wnan.1199.


Poly(ethylene imine)s as Antimicrobial Agents with Selective Activity.
Gibney KA, Sovadinova I, Lopez AI, Urban M, Ridgway Z, Caputo GA, Kuroda K.
Macromol Biosci. 2012 Aug 3. doi: 10.1002/mabi.201200052.

Antibacterial mechanism of action of arylamide foldamers.
Mensa B, Kim YH, Choi S, Scott R, Caputo GA, DeGrado WF.
Antimicrob Agents Chemother. 2011 Nov;55(11):5043-53. Epub 2011 Aug 15.
PMID: 21844313

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives.
Sovadinova I, Palermo EF, Urban M, Mpiga P, Caputo GA, Kuroda, K
Polymers, 2011, 3, 1512-1532.
DOI:10.3390/polym3031512

Exciton annihilation and energy transfer in self-assembled peptide-porphyrin complexes depends on peptide secondary structure.
Kuciauskas D, Kiskis J, Caputo GA, Gulbinas V.
J Phys Chem B. 2010 Dec 9;114(48):16029-35. Epub 2010 Nov 11.
PMID: 21069973

Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
Ivankin A, Livne L, Mor A, Caputo GA, Degrado WF, Meron M, Lin B, Gidalevitz D.
Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8462-5. No abstract available.
PMID: 20872385

Self-assembly of peptide-porphyrin complexes leads to pH-dependent excitonic coupling.
Kuciauskas D, Caputo GA.
J Phys Chem B. 2009 Oct 29;113(43):14439-47.
PMID: 19845410

The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives.
Kuroda K, Caputo GA, DeGrado WF.
Chemistry. 2009;15(5):1123-33.

pH-induced conformational change of the influenza M2 protein C-terminal domain.
Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP.
Biochemistry. 2008 Sep 23;47(38):9934-6. Epub 2008 Aug 29.
PMID: 18754675

Computationally designed peptide inhibitors of protein-protein interactions in membranes.
Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H.
Biochemistry. 2008 Aug 19;47(33):8600-6. Epub 2008 Jul 22.
PMID: 18642886

Peptide probes for protein transmembrane domains.
Slivka PF, Wong J, Caputo GA, Yin H.
ACS Chem Biol. 2008 Jul 18;3(7):402-11. Review.
PMID: 18533658

Computational design of peptides that target transmembrane helices.
Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF.
Science. 2007 Mar 30;315(5820):1817-22.
PMID: 17395823

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS.
J Biol Chem. 2006 Dec 1;281(48):36732-41. Epub 2006 Oct 10.
PMID: 17032655

Position and ionization state of Asp in the core of membrane-inserted alpha helices control both the equilibrium between transmembrane and nontransmembrane helix topography and transmembrane helix positioning.
Caputo GA, London E.
Biochemistry. 2004 Jul 13;43(27):8794-806.
PMID: 15236588

The effect of interactions involving ionizable residues flanking membrane-inserted hydrophobic helices upon helix-helix interaction.
Lew S, Caputo GA, London E.
Biochemistry. 2003 Sep 16;42(36):10833-42.
PMID: 12962508

Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae.
Kim H, Yan Q, Von Heijne G, Caputo GA, Lennarz WJ.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7460-4. Epub 2003 Jun 16.
PMID: 12810948

Cumulative effects of amino acid substitutions and hydrophobic mismatch upon the transmembrane stability and conformation of hydrophobic alpha-helices.
Caputo GA, London E.
Biochemistry. 2003 Mar 25;42(11):3275-85.
PMID: 12641459

Using a novel dual fluorescence quenching assay for measurement of tryptophan depth within lipid bilayers to determine hydrophobic alpha-helix locations within membranes.
Caputo GA, London E.
Biochemistry. 2003 Mar 25;42(11):3265-74.
PMID: 12641458

Interaction of the membrane-inserted diphtheria toxin T domain with peptides and its possible implications for chaperone-like T domain behavior.
Hammond K, Caputo GA, London E.
Biochemistry. 2002 Mar 5;41(9):3243-53.
PMID: 11863463

Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion.
Dhanvantari S, Arnaoutova I, Snell CR, Steinbach PJ, Hammond K, Caputo GA, London E, Loh YP.
Biochemistry. 2002 Jan 8;41(1):52-60.
PMID: 11772002