Viral Pathogenesis Lab

Recent Publications

Petermann P., E. Rahn, K. Thier, M.J. Hsu, F. Rixon, W. Bloch, S. Özcelik, C. Krummenacher, M.J. Barron, M.J. Dixon, S. Scheu, K. Pfeffer, D. Knebel-Mörsdorf. 2015. Entry mechanisms of Herpes Simplex Virus Type 1 into murine skin: Involvement of nectin 1 and HVEM as cellular receptors. J.Virol. 89:262-274.

Cairns T.M., Z.Y. Huang, J.C. Whitbeck, M. Ponce-de-León, H. Lou, A. Wald, C. Krummenacher, R.J. Eisenberg, and G.H. Cohen. 2014. Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans. J. Virol. 88:12612-22.

Bello-Morales R., A.J. Crespillo, B. García, L.A. Dorado, B. Martín, E. Tabarés, C. Krummenacher, F. de Castro, J.A. López-Guerrero. 2014. The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells. PLOS One 9(2):e89141.

Lazear E., J.C. Whitbeck, Y. Zuo, A. Carfí, G.H. Cohen, R.J. Eisenberg and C. Krummenacher. 2014. Dynamics of conformational changes at the N-terminus of herpes simplex virus glycoprotein D induced by HVEM and nectin-1. Virology 448;185-95. 

Fantin M., M.A. van der Kooij, J. Grosse, C. Krummenacher and C. Sandi. 2013. A key role for nectin-1 in the ventral hippocampus in contextual fear memory. PLOS ONE 8(2): e56897.

Shelly S.S., T.M. Cairns, J.C. Whitbeck, C. Krummenacher, G.H. Cohen, and R.J. Eisenberg. 2012. The membrane proximal region (MPR) of herpes simplex virus gB regulates association of the fusion loops with lipid membranes. mBio. 3(6):e00429-12.

Lazear E., J.C. Whitbeck, M. Ponce de Leon, T.M. Cairns, Y. Zuo, C. Krummenacher, G.H. Cohen and R.J. Eisenberg. 2012. Antibody-induced conformational changes in HSV gD reveal new targets for virus neutralization. J. Virol. 86:1563-76.

Di Giovine P., E.C. Settembre, A.K. Bhargava, M.A. Luftig, H. Lou, G.H. Cohen, R.J. Eisenberg, C. Krummenacher and A. Carfi. 2011. Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. PLOS Pathogens. 7(9): e1002277.

Stiles K.M., J.C. Whitbeck, H. Lou, G.H. Cohen, R.J. Eisenberg and C. Krummenacher. 2010. Herpes simplex virus glycoprotein D interferes with HVEM binding to its ligands through down-regulation and direct competition. J. Virol. 84:11646-60.

Stiles K.M. and C. Krummenacher. 2010. Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry. Virology. 399:109-19 and cover.

Reviews, editorials and book chapters

Krummenacher C., A. Brown, T. Edrington V, B.J. Shenker and K. Boesze-Battaglia. 2011. Mechanisms by which pathogens hijack and utilize membrane domains to mediate cytotoxicity. In P.L. Yeagle, ed. The Structure of Biological Membranes, 3^rd edition. CRC Press. Boca Raton, FL.

Eisenberg R.J., E.E. Heldwein, G.H. Cohen and C. Krummenacher. 2011. Recent progress in understanding herpes simplex virus entry: relationship of structure to function. In S.K. Weller, ed. Alpha Herpesviruses: Molecular and Cellular Biology. Horizon Scientific Press, Norwich, UK.

Harty R.N., A.P. Schmitt, F. Bouamr, C.B. Lopez and C. Krummenacher. 2011. Virus budding/Host interactions. Advances in Virology, 2011:963192. Editorial.

Eisenberg R.J., D. Atanasiu, T.M. Cairns, J.R. Gallagher, C. Krummenacher and G.H. Cohen. 2012. Herpes virus fusion and entry: A story with many characters. Viruses, 4:800-832.

Krummenacher C., A.Carfi, R.J. Eisenberg and G.H. Cohen. 2013. Herpesvirus entry into cells: The Enigma Variations. Adv. Exp. Med. Bio. 790:178-95.

Also in S. Pöhlmann and G. Simmons, eds. Viral entry into host cells. Landes Bioscience, Austin TX. Online edition: http://www.landesbioscience.com/curie/chapter/3035/

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