organic synthesis · chemical biology· medicinal chemistry


Full Publication List

Independant Publications :

20.  Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives Capilato, J.N.; Pellegrinelli, P.J.; Bernard, J.; Schnorbus, L.; Philippi, S.; Mattiucci, J.; Hoy, E.P.; Perez, L.J. Organic & Biomolecular Chemistry, 2021, 19(24):5298-5302.

19.  Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States White B.; Sterrett J.D.; Grigoryan Z.; Lally L.; Heinze J.D.; Alikhan H.; Lowry C.A.; Perez L.J.; DeSipio J.; Phadtare S. World J Gastroenterol, 2021, 27(33):5575-5594.

18.  Parallel quorum-sensing system in Vibrio cholerae prevents signal interference inside the host  Watve S.; Barrasso K.; Jung S.A.; Davis K.J.; Hawver L.A.; Khataokar A.; Palaganas R.G.; Neiditch M.B.; Perez L.J.; Ng W.L. PLoS Pathogens, 2020, 16(2):e1008313.

17.  Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles Flockton, T.R.; Schnorbus, L.; Araujo, A.; Adams, J.; Hammel, M.; Perez, L.J. Pathogens, 2019, 24; 8(2):55.

16. Development of a Novel Series of Non-natural Triaryl Agonists and Antagonists of the Pseudomonas aeruginosa LasR Quorum Sensing Receptor Capilato, J.N.; Philippi, S.V.; Reardon,T.; McConnell, A.; Oliver, D.C.; Warren, A.; Adams, J.S.; Wu, C.; Perez. L.J. Bioorganic and Medicinal Chemistry, 2017, 25(1), 153-165.

15. Lipoxin A4 Augments Host Defense in Sepsis and Reduces Pseudomonas aeruginosa Virulence Through Quorum Sensing Inhibition Wu, B.; Capilato, J.N.; Pham, M.P.; Walker, J.; Spur, B.; Rodriguez, A.; Perez, L.J.; Yin, K. The FASEB Journal, 2016, 30(6), 2400-2410.

14. Illuminating Bacterial Communication (Invited Review Article) Capilato, J.N.; Perez, L.J. International Journal of Luminescence and Applications, 2016, 1, 1-4.

13. Potent Irreversible Inhibitors of Quorum Sensing Regulated Virulence in Pseudomonas aeruginosa O’Brien, K.T.; Noto, J.G.; Nichols-O’Neill, L.; Perez, L.J. ACS Medicinal Chemistry Letters, 2015, 6, 162-167.

ACS Med Chem Lett

12. Modulating Vibrio cholerae Quorum Sensing Controlled Communication Using Autoinducer-Loaded Nanoparticles. Lu, H.D; Spiegel, A.C.; Hurley, A.; Perez, L.J.; Maisel, K.; Ensign, L.M.; Hanes, J.; Bassler, B.L.; Semmelhack, M.F.; Prud’homme, R.K. Nano Letters, 2015, 15(4), 2235-2241.


11. Caenorhabditis elegans Recognizes a Bacterial Quorum-sensing Signal Molecule through the AWCON Neuron. Werner, K.M.; Perez, L.J.; Ghosh, R.; Semmelhack, M.F.; Bassler, B.L. Journal of Biological Chemistry, 2014 289(38), 26566-26573.


Undergraduate, Graduate and Postdoctoral Publications:

10. Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae. Perez, L.J.; Karagounis, T.K.; Hurley, A.; Bassler, B.L. and Semmelhack, M.F. Chemical Science ,2014, 5, 151-155.


9. The Role of the CAI-1 Fatty Acid Tail in the Vibrio cholerae Quorum Sensing Response. Perez L.J.; Ng W.L.; Marano P.; Brook K.; Bassler B.L.; Semmelhack M.F. Journal of Medicinal Chemistry, 2012, 55 (22), 9669-9681.


8. Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios. Ng W.L.; Perez L.J.; Cong J.; Semmelhack M.F.; Bassler B.L. PLoS Pathogens, 2012, 8(6): e1002767. doi:10.1371/journal.ppat.1002767


7. Small Molecule Probes of the Receptor Binding Site in the Vibrio cholerae CAI-1 Quorum Sensing Circuit.Bolitho, M.E.*; Perez, L.J.*; Koch, M.J.; Ng, W.L.; Bassler, B.B.; and Semmelhack, M.F. Bioorganic & Medicinal Chemistry, 2011, 19, 6906-6918. *Contributed equally.


6. Investigation of Vibrio cholerae autoinducer-1 biosynthesis - (S)-adenosylmethionine is the in vivo substrate for CqsA. Wei, Y.; Perez, L.J.; Ng, W.L.; Semmelhack, M.F.; and Bassler, B.L. ACS Chemical Biology 2011, 6, 356-365. This research made the journal cover!


5. Signal production and detection specificity in the Vibrio CqsA/CqsS quorum-sensing systems Ng, W.L.; Perez, L.J.; Wei, Y.; Kraml, C.; Semmelhack, M.F. 2011, 79, 6, 1407-1417. This work was highlighted in: Winans, S.C. “A new family of quorum sensing pheromones synthesized using S-adenosylmethionine and Acyl-CoAs” Molecular Microbiology, 2011, 79, 6, 1403-1406.

Signaling Molecules

4. Probing bacterial transmembrane histidine kinase receptor–ligand interactions with natural and synthetic molecules. Ng, W.L.; Wei, Y.; Perez, L.J.; Cong, J.; Long, T.; Koch, M.J.; Semmelhack, M.F.; Wingreen, N.S.; and Bassler, B.L. Proceedings of the National Academy of Sciences of the United States of America 2010, 107, 12, 5575-5580.


3. Stereoselective Synthesis of Trisubstituted (E,E)-1,3-Dienes by the Site-Selective Reductive Cross-Coupling of Internal Alkynes with Terminal Alkynes: A Fragment Coupling Reaction for Natural Product Synthesis. Perez, L.J.; Shimp, H.L.; and Micalizio, G.C. Journal of Organic Chemistry, 2009, 74, 7211-7219. This work was published as a selected "Featured Article" and was highlighted in: ChemInform, 2010, 41, 7.


2. Titanium-Mediated Fragment Union Processes in Complex Molecule Synthesis: Development of a Branched Reaction Pathway of High Step Economy for the Synthesis of Complex and Diverse Polyketides. Perez, L.J. and Micalizio, G.C. Synthesis, 2008, 4, 627-648. This work was published as an invited "Featured Article".


1. Bistratamides E-J, Modified Cyclic Hexapeptides from the Philippines Ascidian Lissoclinum bistratum. Perez, L.J. and Faulkner, D.J. Journal of Natural Products 2003, 66, 247-250.